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Typical concentrations range from ~0.1 mM to 10 mM , depending on: Cell type (e.g., hepatocytes, neuronal cells, fibroblasts) Oxidative stress conditions (e.g., HO exposure models) Duration of exposure (acute vs

33 , 34 After oral administration, absorption of glutathione is very poor mainly due to hydrolysis by intestinal and hepatic -glutamyltransferase as mentioned above, and for that reason, most therapeutic approaches using the oral route struggle to achieve results and the patients seek less safe treatments like intravenous treatment often under uncontrolled situations which may not be medically supervised, in some countries

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Its approximately 24-hour half-life supports once-daily administration, making it convenient for sustained study protocols

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7 While antithrombotic agents have different mechanisms of action, they increase the risk of bleeding correlated to the potency of the drug